Sep 30, 2019
Choline supplementation may be one important key to preventing the dread dementia of aging. A mouse model study by the Arizona State University finds that choline blocks formation of amyloid plaques and reduces numbers of microglial scavenger cells that damage normal brain cells.
The researchers fed their experimental animals, genetically prone to develop Alzheimer’s, an amount of choline 4.5 times that of the traditional recommended daily amount but half the allowable daily max. Only the treated animals maintained normal cognitive abilities and performed well in a maze test.
Choline is found in eggs, beef, pork, chicken, turkey, fish, mushrooms, and readily available oral supplements. The study suggests a daily consumption level of about 2500 mg. For men and 2000 mg for women.
Ramon Velazquez, Eric Ferreira, Sara Knowles, Chaya Fux, Alexis Rodin, Wendy Winslow, Salvatore Oddo. Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell, 2019; DOI: 10.1111/acel.13037