Feb 22, 2019
Vidcast: https://youtu.be/OeVhgDxUB-g
Vaginal yeast infections are all too common and during pregnancy are frequently treated with oral fluconazole or the branded Diflucan. New data from over 400,000 pregnancies in Quebec reviewed at the University of Montreal shows that any dose of oral fluconazole is associated with a higher incidence of miscarriage.
Fluconazole is known for its induction of lethal genetic defects including heart defects as well as miscarriage, but most warnings about the drug mention doses of the drug higher than 400-800 mg per day. The current study shows that congenital cardiac defects arose after exposures to 150 mg per day or above during early pregnancy, and, let me repeat, any dose of oral fluconazole is associated with a higher incidence of miscarriage.
Once again, the byword is that any oral medications during pregnancy should be avoided.
#yeast #vaginitis #fluconazole #diflucan #miscarriage #cardiacdefects #healthnews #healthtips
Anick Bérard, Odile Sheehy, Jin-Ping Zhao, Jessica Gorgui, Sasha Bernatsky, Cristiano Soares de Moura, Michal Abrahamowicz. Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case–control studies. Canadian Medical Association Journal, 2019; 191 (7): E179 DOI: 10.1503/cmaj.180963
Vanessa Cristine Paquette, Chelsea Elwood. The safety of oral fluconazole therapy in pregnancy. Canadian Medical Association Journal, 2019; 191 (7): E177 DOI: 10.1503/cmaj.190079